When science approaches the edge of meaning
Here is what I think…
As a scientist working at the intersection of molecular genetics, translational biology, and the emerging exploration of life’s multiple codes, including the challenging spatial dimension of biological information, we are trained to search for mechanisms, patterns, and causal order. Our daily work unfolds within time, across scales, and through processes that depend on sequence, regulation, and emergence. Yet alongside this rigorous engagement with measurable reality, many of us carry a quieter, persistent curiosity about time itself, about origins, about awareness, and about the strange fact that a universe governed by impersonal laws has given rise to beings capable of reflecting on its vastness. This review grows from that tension. It does not attempt to dissolve scientific precision into abstraction, nor does it seek refuge in metaphysical certainty. Instead, it follows a series of uncomfortable inquiries that arise naturally when scientific understanding reaches its conceptual limits, inviting everyone to examine how scale, time, and awareness reshape our sense of meaning without betraying the integrity of science itself.
Before the beginning, the question science cannot place in time
We begin where scientific language itself starts to hesitate. When we say that the universe is approximately 13.8 billion years old, we often speak as if we were describing an object that appeared within time. Yet our own theories force us to accept something far more unsettling: time itself is part of what came into existence. In the framework of general relativity, time is woven together with space into a single dynamical structure. The Big Bang is therefore not an explosion occurring at a moment in time; it is the point at which time, as a physical dimension, becomes meaningful. Asking what happened before that moment immediately exposes a conceptual fracture, because “before” presupposes the very thing whose origin we are trying to describe.
We encounter here a limit that is not technological, nor experimental, but cognitive. Science is extraordinarily powerful at describing evolution, transformation, and causality once a temporal framework is in place. It struggles, however, when confronted with the emergence of that framework itself. Various cosmological models attempt to soften this boundary. Quantum cosmology proposes primordial states governed by probabilities rather than classical trajectories. Inflationary scenarios suggest a larger backdrop in which universes like ours may nucleate. Cyclic and bouncing models replace a singular beginning with eternal recurrence or contraction followed by expansion. Yet in all these cases, the sense of temporal sequence dissolves at the deepest level. What replaces it is mathematical structure, symmetry, or law, none of which answers the intuitive question that continues to trouble us: why is there something rather than nothing?
This persistence of the question is revealing. It suggests that the problem is not simply incomplete physics. Even if tomorrow we were to discover a final, self-consistent theory describing the emergence of spacetime from more fundamental entities, the question of origin would simply relocate. Why those entities? Why those laws? Why existence at all? Science, faithful to its own discipline, does not claim authority over such questions. It explains conditions, constraints, and consequences. It does not assign intention, necessity, or purpose. The discomfort arises when we realize that our minds continue to ask questions that our best tools are not designed to answer.
Scale intensifies this discomfort. When we place a human lifespan against cosmic time, the contrast is almost absurd. A few decades unfold within a universe that has been evolving for billions of years and may continue for billions more. Yet the brevity of our existence does not invalidate our inquiry. On the contrary, it sharpens it. A fleeting conscious life is still capable of formulating questions that span eternity, which in itself is a remarkable fact. The universe, vast and indifferent to duration, has nevertheless given rise to entities capable of reflecting on its origin.
At this point, we sense a quiet shift. The question “what was there before the universe?” begins to reveal itself as less a scientific query and more a mirror held up to our own need for intelligibility. It is awareness, not spacetime, that insists on continuity, explanation, and narrative. When science tells us that the question may be meaningless within our current understanding, it is not silencing curiosity. It is revealing that some questions originate from the structure of consciousness itself rather than from the structure of the universe.
This realization does not diminish science. It deepens it. It invites all of us to recognize that the origin problem marks a boundary where explanation gives way to acknowledgment. The universe may not offer an answer to its own beginning, and yet the fact that such a question arises at all, within a finite and fragile awareness, remains one of the most striking features of existence. Here, at the edge of time, we encounter not a failure of knowledge, but the first clear sign that understanding the universe may ultimately require understanding the one who asks.

A vast and silent universe
As soon as we lift our gaze from origins to scale, a second discomfort emerges, quieter yet equally destabilizing. The universe is not just old; it is vast beyond any intuitive grasp. Even the observable universe, bounded by the finite speed of light and the age of cosmic expansion, spans tens of billions of light-years in every direction. Beyond that horizon, space may continue indefinitely, structured by the same laws yet forever inaccessible. This immensity erodes any lingering sense of centrality. There is no privileged location, no cosmic vantage point from which the universe is arranged around us. We occupy no more than a temporary address in an unremarkable region of a universe that offers no spatial hierarchy.
Within this immensity, probability takes the place once occupied by destiny. Modern astronomy has shown that planets are common, that planetary systems form as a natural consequence of star formation, and that Earth-like conditions may arise wherever chemistry, energy, and time are available. From this perspective, life elsewhere becomes not a bold speculation but a statistical expectation. Given enough galaxies, enough stars, and enough time, the emergence of life begins to look almost inevitable. Yet inevitability here carries no promise. The universe may be fertile, even exuberant, in producing life, while remaining entirely indifferent to it.
This realization unsettles a deeply rooted hope: that abundance implies significance. Even if life has arisen countless times across the cosmos, even if intelligence and self-awareness have emerged on innumerable worlds, nothing in our physical theories suggests that these occurrences are coordinated, directed, or convergent. Evolution operates locally, shaped by contingency rather than intention. Awareness may bloom repeatedly, yet remain scattered, isolated, and transient. The universe, from this vantage point, appears generous in possibility and silent in response.
Relativity sharpens this silence. The finite speed of light imposes an absolute constraint on connection. Civilizations separated by millions of light-years do not share a common present. What one sees of the other belongs irreversibly to the past. Even in principle, no technological advance can overcome this limit without abandoning the very structure of spacetime as we understand it. Encounters remain asymptotic fantasies. Signals arrive too late, journeys take longer than civilizations endure, and synchronization dissolves into irrelevance. Intelligent life may be everywhere, and yet functionally alone.
Here, the idea of cosmic isolation takes on a new form. It is not that the universe is empty; it may be richly populated. It is that its architecture prevents communion. Each island of awareness unfolds within its own causal bubble, unable to confirm whether it is unique or one among many. The search for extraterrestrial intelligence, when viewed through this lens, becomes less a quest for contact and more a reflection of our own need to know whether our experience is shared.
In this context, the notion of privilege quietly collapses. We are not the center of creation, nor its culmination. We are not guaranteed an audience, a counterpart, or a role in a larger cosmic narrative. Probability replaces purpose with unsettling efficiency. Events occur because conditions allow them to occur. Life arises because chemistry permits complexity. Awareness appears because nervous systems reach sufficient depth. None of this requires a goal.
And yet, the psychological consequences of this view are profound. When the universe offers no assurance of meaning, meaning becomes local, fragile, and provisional. It is no longer granted by scale, rarity, or cosmic significance. It must arise within the narrow window of experience available to each conscious being. The vast and silent universe does not negate meaning; it refuses to supply it. In doing so, it confronts us with a responsibility we did not ask for but cannot evade: in a cosmos ruled by probability, any sense of purpose must be generated from within awareness itself, or not at all.
When “Why” has no address
As we follow scientific explanation to its furthest reach, the question of why begins to lose its footing. Physics describes how structures emerge, how systems evolve, and how complexity unfolds under well-defined constraints. It does so with remarkable precision and increasing scope. Yet at no point does intention appear. Laws do not strive, constants do not prefer outcomes, and the universe exhibits no detectable inclination toward meaning. Teleology, once woven into early cosmologies, has quietly vanished from scientific language, leaving behind a world governed by necessity and chance.
This absence forces a subtle but decisive shift. The question of “why” does not vanish; it relocates. It no longer addresses the universe as an object with intentions, but awareness as the condition that demands explanation. We do not ask why galaxies form or why stars burn; those questions resolve into mechanisms. We ask why existence matters, why experience feels significant, why the fact of being here calls for interpretation. These questions arise nowhere in spacetime itself. They arise within consciousness.
Awareness occupies a peculiar position in our scientific worldview. On one hand, it is studied as an emergent phenomenon, arising from neural complexity, shaped by evolution, and constrained by biology. On the other hand, it resists full reduction. No description of neural activity, however detailed, captures the first-person fact of experience. The feeling of presence, the sense of being, the capacity to care, to suffer, to wonder, remain irreducible features of conscious life. This does not place awareness outside nature, but it does suggest that something essential is lost when we attempt to describe it solely from the outside.
If the universe contains no inherent purpose, then meaning cannot be uncovered like a hidden law. It must be enacted. It comes into being through experience, relation, and interpretation. In this view, awareness does not discover meaning embedded in the cosmos; it generates meaning through engagement with it. This is not a weakness of the human condition; it may be its defining feature. Meaning becomes contextual rather than absolute, provisional rather than eternal, yet no less real for being so.
Here, the discomfort reaches its peak. The universe may offer no justification for itself. It may exist without reason, without aim, without final explanation. Such a conclusion feels almost intolerable, as if it leaves us suspended over an abyss of arbitrariness. Yet awareness does not dissolve in the face of this possibility. It continues to experience, to reflect, to respond. Even in the absence of cosmic endorsement, experience retains its weight.
Perhaps this is the final inversion. The universe does not answer to our need for meaning. Awareness answers to itself. In a cosmos silent on the question of purpose, the act of caring, of understanding, of bearing witness becomes significant precisely because it is not guaranteed. Awareness may be brief, scattered, and contingent, yet wherever it appears, the universe acquires an interior. And within that interior, the question of why survives, not as a demand for explanation, but as an expression of what it means to be conscious at all.
Epilogue
As we bring these uncomfortable explorations to a close, we speak simultaneously to colleagues in the scientific community, to our students, and to anyone willing to pause and reflect on their place in this vast and silent universe. Science remains our most reliable way of understanding how reality unfolds, and its strength lies precisely in its refusal to invent answers where none can be justified. Yet reaching the edges of explanation does not signal failure; it signals maturity. For students, this is an invitation to cultivate intellectual courage, to embrace uncertainty without abandoning rigor, and to recognize that asking deep questions is not a detour from science but one of its most human expressions. For the broader public, these reflections offer reassurance that wonder, humility, and meaning need not disappear in a universe stripped of cosmic privilege. Awareness, fleeting as it may be, remains capable of depth, responsibility, and care. In a world where the universe does not tell us what we are for, we are still free to decide how we inhabit the brief moment of presence we are given, and to do so with clarity, integrity, and compassion.
Best wishes to all,
Prof. Fahd Nasr
Copyright 2026 Prof. Nasr, All rights reserved.








